You asked
Is the canon ts e 135mm f 4l macro hard to focus manually?
The site doesn't say how hard this lens is to focus by hand, so I can't give you a verdict on that. What I can tell you is that it's manual focus only, so you'll turn the ring yourself every time. At f/4 on full frame, depth of field is thin, so you'll need to place the focus carefully on your subject.
On an APS-C Canon, the lens frames like 216mm and f/4 gives about the depth of field of f/6.4, which is a little more forgiving. The Sensor sizes page explains the trade-off between the two.
If you're deciding whether it suits you, the Canon TS-E 135mm f/4L Macro page lists every Canon body it fits, from the full-frame Canon EOS 5D Mark IV to APS-C models like the Canon EOS 90D.
Written by Claude from this site's pages.