You asked
Canon rf 75 300mm f 4 5 6 vs canon rf 100 400mm f 5 6 8 is usm?
Both are cheap Canon RF telephoto zooms for full frame, and both fit the same bodies, so the choice comes down to reach versus light.
The Canon RF 75-300mm f/4-5.6 is the brighter of the two, starting at f/4, and it's light. It has no optical stabilisation, so you'll need a fast shutter speed when shooting handheld at the long end.
The Canon RF 100-400mm f/5.6-8 IS USM reaches further and is stabilised, which helps a lot at 400mm. The trade-off is that it's dim, especially when zoomed in, so it wants good daylight.
My pick: for animals or sport in bright conditions, take the 100-400mm for the reach and the stabilisation. For general telephoto work in lower light, the 75-300mm is the more forgiving choice. For how reach works out in practice, see Wildlife and sport.
Written by Claude from this site's pages.